New platinum derivatives selectively cause double-strand DNA breaks and death in naïve and cisplatin-resistant cholangiocarcinomas
This study introduces a novel therapeutic strategy designed to induce frequent double-strand DNA breaks selectively in both naïve and cisplatin-resistant cancer cells, without evident toxic side effects at therapeutic doses. This approach may form the basis for new strategies to overcome the critical challenge of drug resistance in cancer treatment and has the potential to be a breakthrough not only for the treatment of biliary tumors but also for other cancers.
Authors
- José J.G. Marı́n (ORCID: https://orcid.org/0000-0003-1186-6849)
- Sumera I. Ilyas (ORCID: https://orcid.org/0000-0002-2709-3003)
- Aitziber Eleta-Lopez (ORCID: https://orcid.org/0000-0002-2498-1857)
- Laura Izquierdo‐Sánchez (ORCID: https://orcid.org/0000-0002-7016-8314)
- Fernando P. Cossío (ORCID: https://orcid.org/0000-0002-4526-2122)
- Maider Huici-Izagirre
- Ainhoa Lapitz (ORCID: https://orcid.org/0000-0002-7928-5760)
- Xabier López (ORCID: https://orcid.org/0000-0002-2711-3588)
- Elisa Herráez (ORCID: https://orcid.org/0000-0001-9271-3320)
- Óscar Briz (ORCID: https://orcid.org/0000-0001-6891-1554)
- Pedro M. Rodrigues (ORCID: https://orcid.org/0000-0001-6193-7436)
- Chiara Braconi (ORCID: https://orcid.org/0000-0003-4835-1259)
- María J. Perugorria (ORCID: https://orcid.org/0000-0002-7636-0972)
- David De Sancho (ORCID: https://orcid.org/0000-0002-8985-2685)
- Colin J. Rae (ORCID: https://orcid.org/0000-0003-4432-6670)
- Francisco J. Caballero‐Camino (ORCID: https://orcid.org/0000-0002-6160-5906)
- Maitane Asensio (ORCID: https://orcid.org/0000-0002-8723-6053)
- Alexander M. Bittner (ORCID: https://orcid.org/0000-0003-4815-2444)
- Paula Olaizola (ORCID: https://orcid.org/0000-0002-1358-5429)
- Mikel Odriozola‐Gimeno (ORCID: https://orcid.org/0000-0002-8007-4637)
- Iván Rivilla (ORCID: https://orcid.org/0000-0003-1984-7183)
- Amanda Ribeiro Guimarães (ORCID: https://orcid.org/0000-0001-8732-1699)
- Jesús M. Bañales (ORCID: https://orcid.org/0000-0002-5224-2373)
- Luís Bujanda (ORCID: https://orcid.org/0000-0002-4353-9968)
- Irene Olaizola (ORCID: https://orcid.org/0000-0002-5634-8909)
- Teresa Miranda
- Beatriz Val (ORCID: https://orcid.org/0009-0000-0011-1980)
- Ana Martinez-Amesti
- Noelia Pastor-Toyos
- Mireia Tena-Garitaonandia
Institutions
- Ikerbasque (ES)
- University of the Basque Country (ES)
- Beatson West of Scotland Cancer Centre (GB)
- Biogipuzkoa Health Research Institute (ES)
- CIC nanoGUNE (ES)
- Mayo Clinic in Arizona (US)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Donostia International Physics Center (ES)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1016/j.jhep.2025.04.034
- Citations
- 8
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 16.05