Exploring the role of miRNAs in Hepatocellular Carcinoma: Insights into signaling pathways and their regulatory mechanisms

This study demonstrates that miRNAs, particularly Hsa-miR-20a-5p and Hsa-miR-34a-5p, may regulate the Wnt/β-catenin pathway and influence the progression of HCC. Disease progression was assessed by comparing miRNA expression levels with clinical markers (such as γ-glutamyl transferase and albumin). High expression of Hsa-miR-20a-5p affects the Wnt/β-catenin pathway and plays a significant role in disease processes. Additionally, the correlation between Hsa-miR-34a-5p and γ-glutamyl transferase indicates disease progression. However, further advanced studies are required to better understand how the Wnt/β-catenin pathway is regulated by miRNAs and the impact of this regulation on the disease.