Regulation of iodide transportation by a plant secondary metabolite in SW1736 anaplastic thyroid cancer cell line
The expression of NIS and subsequent iodine uptake after Genistein treatment suggest that ATC cells may be becoming more like differentiated thyroid cells, which typically have higher iodine uptake capabilities. However, this redifferentiation does not directly correlate with an increase in sensitivity to radioactive iodine treatment.
Authors
- Shabnam Heydarzadeh (ORCID: https://orcid.org/0000-0002-9398-9211)
- Mehdi Hedayati (ORCID: https://orcid.org/0000-0001-5816-775X)
- Maryam Sadat Daneshpour (ORCID: https://orcid.org/0000-0002-2208-6568)
- Ali Asghar Moshtaghie
Institutions
- Islamic Azad University, Isfahan (IR)
- Islamic Azad University of Falavarjan (IR)
- Research Institute for Endocrine Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1007/s12672-025-02339-z
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shahid Beheshti University of Medical Sciences
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences