Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
For a strong AD-associated locus near Clusterin (CLU), we connected an AD protective allele to a role of neuronal CLU in promoting neuron excitability through lipid-mediated neuron-glia communication. Our study provides insights into how CLU confers resilience to AD through neuron-glia interactions.
Authors
- Zhiping P. Pang (ORCID: https://orcid.org/0000-0002-6183-1233)
- Matthew J. Moulton (ORCID: https://orcid.org/0000-0003-0228-7669)
- Alan R. Sanders (ORCID: https://orcid.org/0000-0001-6629-4011)
- Jubao Duan (ORCID: https://orcid.org/0000-0002-7215-3220)
- Hugo J. Bellen (ORCID: https://orcid.org/0000-0001-5992-5989)
- Ari Sudwarts (ORCID: https://orcid.org/0000-0002-3816-4380)
- Alena Kozlova (ORCID: https://orcid.org/0000-0002-7298-7460)
- Lindsey D. Goodman (ORCID: https://orcid.org/0000-0002-9255-3811)
- Gopal Thinakaran (ORCID: https://orcid.org/0000-0001-5523-6780)
- Hanwen Zhang (ORCID: https://orcid.org/0000-0001-8490-918X)
- Siwei Zhang (ORCID: https://orcid.org/0000-0002-1646-063X)
- Yan Li (ORCID: https://orcid.org/0000-0002-5838-3185)
- Xiaojie Zhao (ORCID: https://orcid.org/0000-0002-3243-8774)
Institutions
- Rutgers, The State University of New Jersey (US)
- Baylor College of Medicine (US)
- University of South Florida (US)
- Johnson University (US)
- University of Chicago (US)
- Neurological Research Institute (US)
- Evanston Hospital (US)
- USF Health Byrd Alzheimer's Institute (US)
- Texas Children's Hospital (US)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s13024-025-00840-1
- Citations
- 6
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- BrightFocus Foundation
- National Institute of Mental Health and Neurosciences
- National Institute on Aging
- National Institute of Mental Health