Cochlear inflammation in AAV-mediated gene therapy: serotype-dependent macrophage activation and promoter-driven immunogenicity
These findings highlight serotype- and promoter-dependent immunogenicity as key determinants of cochlear inflammation. Strategic selection of AAV components is essential to balance transduction efficiency and immune tolerance in inner ear gene therapy.
Authors
- Hongdong Liu (ORCID: https://orcid.org/0000-0003-4359-3785)
- Xiaojun Ji
- Xiaochen Ni
- Xihang Chen (ORCID: https://orcid.org/0000-0001-8293-8542)
- Shiming Yang (ORCID: https://orcid.org/0000-0002-7808-2566)
- Wei Chen (ORCID: https://orcid.org/0000-0003-3720-718X)
- Zhifeng Chen (ORCID: https://orcid.org/0000-0001-8901-1002)
- Yi Luo (ORCID: https://orcid.org/0000-0001-5487-1352)
Institutions
- Fujian Medical University (CN)
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- National Clinical Research (US)
Publication Details
- Journal
- Acta Oto-Laryngologica
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1080/00016489.2025.2492366
- Citations
- 2
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Key Research and Development Program of China