Insulin/PHMB-grafted sodium alginate hydrogels improve infected wound healing by antibacterial-prompted macrophage inflammatory regulation
Our findings demonstrate that P-SA/Ins promotes wound healing and restores epidermal barrier integrity, indicating its potential as a therapeutic dressing for chronic wound healing, particularly in cases with infection risk.
Authors
- Yunsheng Chen (ORCID: https://orcid.org/0000-0002-2086-9833)
- Min Gao (ORCID: https://orcid.org/0000-0002-0001-5283)
- He Xu (ORCID: https://orcid.org/0000-0003-2225-4725)
- Lefeng Su
- Dan Liu (ORCID: https://orcid.org/0009-0008-7976-8042)
- Yan Liu (ORCID: https://orcid.org/0000-0003-4242-228X)
- Yan Liu (ORCID: https://orcid.org/0000-0003-4242-4840)
- Shan Ma
- Tianyi Yu (ORCID: https://orcid.org/0000-0001-7959-8401)
- Shan Zhong (ORCID: https://orcid.org/0009-0007-0802-0902)
- Jiaao Yu (ORCID: https://orcid.org/0000-0002-4665-200X)
- Wenao Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Normal University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s12951-025-03398-8
- Citations
- 3
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities