Traditional Chinese medicine Youguiyin decoction ameliorate glucocorticoid-induced osteonecrosis in rat by modulating ROS/PHD2/HIF-1α oxidative stress signaling pathway in bone marrow mesenchymal stem cells
These results provide compelling in vivo and in vitro evidence that YGY decoction may play a role in promoting glucocorticoid-induced osteonecrosis bone repair by targeting the mediation of the ROS/PHD2/HIF-1α oxidative stress signaling pathway, thus providing a new theoretical basis for the clinical application of YGY decoction to glucocorticoid-induced osteonecrosis.
Authors
- Hao Chen (ORCID: https://orcid.org/0000-0002-6546-1815)
- Hongzhong Xi (ORCID: https://orcid.org/0000-0002-4408-7510)
- Guang-quan Sun
- Siqi He (ORCID: https://orcid.org/0000-0002-0784-1270)
- Bin Du (ORCID: https://orcid.org/0000-0002-0101-9673)
- Xin Liu (ORCID: https://orcid.org/0000-0001-8503-7125)
- Jiahao Fu
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s13020-025-01113-1
- Citations
- 4
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.89
Funders
- National Natural Science Foundation of China