Mutation burden of narrowband ultraviolet B phototherapy (NB-UVB) in human skin: relevance to NB-UVB lifetime exposures and skin cancer surveillance
A treatment course of NB-UVB causes UVR-induced mutations in the healthy skin of patients with psoriasis. Relating mutation burden to MED and sun behaviour habits allows estimation of when to begin skin cancer surveillance according to total lifetime NB-UVB exposures.
Authors
- George Coltart (ORCID: https://orcid.org/0000-0001-7648-8741)
- Eugene Healy (ORCID: https://orcid.org/0000-0001-5591-6970)
- Chester Lai (ORCID: https://orcid.org/0000-0003-2282-5655)
- Philip H. Jones (ORCID: https://orcid.org/0000-0002-5904-795X)
- Joanna C. Fowler (ORCID: https://orcid.org/0000-0001-7546-369X)
- John W. Holloway (ORCID: https://orcid.org/0000-0001-9998-0464)
- Matthew Rose‐Zerilli (ORCID: https://orcid.org/0000-0002-1064-5350)
- Roshan Sood (ORCID: https://orcid.org/0000-0002-1318-7025)
- Brian Diffey (ORCID: https://orcid.org/0000-0002-8955-125X)
- Noeline Nadarajah
Institutions
- Chinese University of Hong Kong (HK)
- University of Cambridge (GB)
- Southampton General Hospital (GB)
- Wellcome Sanger Institute (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Clinical Research Institute (US)
- Hutchison/MRC Research Centre (GB)
- University of Southampton (GB)
- Newcastle University (GB)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1093/bjd/ljaf173
- Citations
- 1
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Wellcome Trust
- Psoriasis Association
- Medical Research Council Canada
- Medical Research Council