Exome and transcriptome analysis link calcium channel pathway aberrations to botulinum toxin A resistance in Hailey-Hailey disease
BoNTA treatment in HHD exhibits interindividual variability. Although the type of ATP2C1 mutation has no direct association with patients' response, combined transcriptomic analysis and IHC indicate that upregulation of the ORAI1/SOCE pathway may contribute to treatment resistance and serve as biomarkers to predict patient responsiveness.
Authors
- Hailun Wang (ORCID: https://orcid.org/0000-0003-3061-9456)
- Yiyang Yuan (ORCID: https://orcid.org/0000-0002-6045-5790)
- Han Cao (ORCID: https://orcid.org/0000-0001-9992-9108)
- Li Zhang (ORCID: https://orcid.org/0000-0002-9386-8938)
- Xiaoying Chen (ORCID: https://orcid.org/0000-0003-1068-1738)
- Jie Zheng (ORCID: https://orcid.org/0000-0002-7961-6427)
- Yan Yang (ORCID: https://orcid.org/0000-0003-3510-702X)
- Meng Pan (ORCID: https://orcid.org/0000-0003-4947-9369)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1093/bjd/ljaf112
- Citations
- 1
- Primary Topic
- Genetic and rare skin diseases.
- Type
- article
- Field-Weighted Citation Impact
- 1.82