DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies
These findings demonstrate that PMF driver mutations do not directly evoke epigenetic changes. While PMF shares epigenetic alterations with other myeloid malignancies, DNA methylation patterns can distinguish between PMF and related diseases.
Authors
- Martin Zenke (ORCID: https://orcid.org/0000-0002-1107-3251)
- Steffen Koschmieder (ORCID: https://orcid.org/0000-0002-1011-8171)
- Vithurithra Tharmapalan (ORCID: https://orcid.org/0000-0001-5648-0881)
- Joelle Schifflers
- Kim Kricheldorf (ORCID: https://orcid.org/0000-0003-3102-2221)
- Wolfgang Wagner (ORCID: https://orcid.org/0000-0001-7704-6857)
- Madeline J. Caduc (ORCID: https://orcid.org/0000-0001-9880-4709)
- Esra Dursun Torlak
Institutions
- Universitätsklinikum Aachen (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s13148-025-01877-1
- Citations
- 1
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung