Reduced IGF-1 Levels Following Clomiphene Treatment for Male Hypogonadism
Clomiphene therapy can result in a significant reduction in serum IGF-1 levels in some treated hypogonadal men. Given that the decrease in IGF-1 can be >2 SD in some patients and potentially clinically significant, we recommend interval monitoring of serum IGF-1 levels and symptoms of growth hormone deficiency in patients with hypogonadism treated with clomiphene citrate.
Authors
- Anthony P. Heaney (ORCID: https://orcid.org/0000-0003-3865-0810)
- Nikita Mogar (ORCID: https://orcid.org/0000-0002-9501-8806)
- Dongyun Zhang (ORCID: https://orcid.org/0000-0002-0751-7809)
Institutions
- University of California, Los Angeles (US)
- UCLA Medical Center (US)
- Olive View-UCLA Medical Center (US)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1210/jendso/bvaf078
- Citations
- 2
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.59