Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression
OB mitigated OA progression by binding to HDAC1 and inhibiting p38MAPK signaling, indicating that OB may be a promising drug for the treatment of OA.
Authors
- Yang Gao (ORCID: https://orcid.org/0009-0004-8934-886X)
- Chao Shi (ORCID: https://orcid.org/0000-0002-5129-207X)
- Ke Wang (ORCID: https://orcid.org/0000-0002-5388-8643)
- Yong Gao (ORCID: https://orcid.org/0000-0003-1020-5037)
- Dejuan Kong
Institutions
- Affiliated Hospital of Taishan Medical University (CN)
- Taishan University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s13018-025-05804-1
- Citations
- 2
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61