Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages
The present study successfully designed and developed Man-MSA-mIFNα, which efficiently induces the CD169<sup>+</sup> phenotype in LN macrophages, contributing to the antitumor immunity. The findings suggest that our novel strategy targeting CD169⁺ macrophages could be a promising immunotherapy for cancer patients who are unresponsive to immune checkpoint inhibitors.
Authors
- Kenshiro Hirata (ORCID: https://orcid.org/0000-0002-8963-2228)
- Keishi Yamasaki (ORCID: https://orcid.org/0000-0003-0537-2367)
- Rin Yamada (ORCID: https://orcid.org/0000-0001-9161-1429)
- Yoichi Saito (ORCID: https://orcid.org/0000-0001-9097-7656)
- Yukio Fujiwara (ORCID: https://orcid.org/0000-0002-2074-0597)
- Junji Saruwatari (ORCID: https://orcid.org/0000-0001-6266-1347)
- Kentaro Oniki (ORCID: https://orcid.org/0000-0002-5926-7151)
- Masaki Otagiri (ORCID: https://orcid.org/0000-0001-6244-3825)
- Hiroshi Watanabe (ORCID: https://orcid.org/0000-0001-7620-1894)
- Hiromu Yano (ORCID: https://orcid.org/0000-0003-3985-0259)
- Yuki Mizuta
- Yuki Minayoshi (ORCID: https://orcid.org/0000-0003-2459-0482)
- Ryo Fukuda (ORCID: https://orcid.org/0009-0005-6213-3241)
- Mei Takano
- Cheng Pan (ORCID: https://orcid.org/0000-0002-8884-4405)
- Hitoshi Maeda (ORCID: https://orcid.org/0000-0002-0794-9468)
- Yoshihiro Komohara
- Toru Maruyama
- Shuhei Imoto
Institutions
- Sojo University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s12943-025-02324-8
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Japan Society for the Promotion of Science