Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways
Our findings proposed a novel anti-atherosclerotic mechanism of quercetin by mitigating ox-LDL-elicited senescent phenotype of aortic endothelial cells and macrophages by regulating p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
Authors
- Xiao Liang (ORCID: https://orcid.org/0000-0002-5779-6092)
- Jingyuan Zhang (ORCID: https://orcid.org/0000-0001-9581-1807)
- Shu-sen Yang (ORCID: https://orcid.org/0000-0003-1275-1920)
- Jiyi Zhao
- Jiangbo Yu
Institutions
- Harbin Medical University (CN)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Centre for Cardiovascular Research (DE)
- University Medical Centre Mannheim (DE)
- First Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s40001-025-02562-y
- Citations
- 9
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province