iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025
Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need for universal recommendations that address the unique challenges faced by patients and healthcare providers worldwide. Our iCARDIO Alliance Global Implementation Guidelines emphasize the incorporation of novel therapies, while integrating standard of care with the most up-to-date evidence to enable clinicians to optimize patient care. This document is about heart failure (HF), including acute and chronic heart failure, heart failure with reduced ejection fraction and heart failure with preserved ejection fraction as well as cardiomyopathies. Context-specific recommendations tailored to individual patient needs are highlighted providing a thorough evaluation of the risks, benefits, and overall value of each therapy, aiming to establish a standard of care that improves patient outcomes and reduces the burden of hospitalization in this susceptible population. These guidelines provide evidence-based recommendations that represent a group consensus considering the many other published guidelines that have reviewed many of the issues discussed here, but they also make new recommendations where new evidence has recently emerged. Most importantly these guidelines also provide recommendations on a number of issues where resource limitations may put constraints on the care provided to HF patients. Such "economic adjustment" recommendations aim to provide guidance for situations when "Resources are somewhat limited" or when "Resources are severely limited". Hence, this document presents not only a comprehensive but also concise update to HF management guidelines thereby aiming to provide a unified strategy for the pharmacological, nonpharmacological, invasive and interventional management of this significant global health challenge that is applicable to the needs of healthcare around the globe.
Authors
- Elijah Nyainda Ogola (ORCID: https://orcid.org/0000-0002-6102-9232)
- Lucrecia María Burgos (ORCID: https://orcid.org/0000-0002-3999-1265)
- Clara Saldarriaga (ORCID: https://orcid.org/0000-0002-5945-1127)
- Justin Adrian Ezekowitz (ORCID: https://orcid.org/0000-0002-2724-4086)
- Michael Böhm (ORCID: https://orcid.org/0000-0002-2976-2514)
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- Ishaque Hameed (ORCID: https://orcid.org/0000-0002-3698-6401)
- Maria Rosa Costanzo (ORCID: https://orcid.org/0000-0001-6995-7538)
- Fausto José Pinto (ORCID: https://orcid.org/0000-0002-8034-4529)
- S Harikrishnan (ORCID: https://orcid.org/0000-0002-7509-0712)
- Amina Rakisheva (ORCID: https://orcid.org/0000-0001-9842-962X)
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- P. Christian Schulze
- Anuradha Lala (ORCID: https://orcid.org/0000-0001-6479-6958)
- L W Stevenson
- Rhonda E. Monroe (ORCID: https://orcid.org/0009-0001-0989-662X)
- Fernando Bacal (ORCID: https://orcid.org/0000-0001-7603-2752)
- Dulce Brito (ORCID: https://orcid.org/0000-0003-1278-1847)
- Andrew Paul Sindone (ORCID: https://orcid.org/0000-0003-0075-805X)
- Tiny Jaarsma (ORCID: https://orcid.org/0000-0002-4197-4026)
- Andrew J.S. Coats (ORCID: https://orcid.org/0000-0002-2771-4260)
- Marvin A. Konstam (ORCID: https://orcid.org/0000-0001-6163-8399)
- John James Atherton (ORCID: https://orcid.org/0000-0003-2271-578X)
- Nqoba Tsabedze (ORCID: https://orcid.org/0000-0002-7210-1447)
- Ralph Stephan von Bardeleben (ORCID: https://orcid.org/0000-0002-1356-0037)
- Harriette G.C. Van Spall (ORCID: https://orcid.org/0000-0002-8370-4569)
- William T. Abraham (ORCID: https://orcid.org/0000-0003-4805-1037)
- Juan Esteban Gómez‐Mesa (ORCID: https://orcid.org/0000-0002-6635-6224)
- Vijay Chopra (ORCID: https://orcid.org/0000-0001-9512-1718)
- Tzung‐Dau Wang (ORCID: https://orcid.org/0000-0002-7180-3607)
- Yuhui Zhang (ORCID: https://orcid.org/0000-0002-2382-8869)
- Shelley R. Zieroth (ORCID: https://orcid.org/0000-0002-6145-9814)
- Hadi Skouri (ORCID: https://orcid.org/0000-0003-0541-4926)
- Naoki Sato (ORCID: https://orcid.org/0000-0002-6429-0591)
- Mohammad Zubaid (ORCID: https://orcid.org/0000-0003-4588-3292)
- Albertino Antonio Moura Damasceno (ORCID: https://orcid.org/0000-0003-0925-494X)
- Magdy Abdelhamid (ORCID: https://orcid.org/0000-0002-6701-7072)
- Hiroyuki Tsutsui (ORCID: https://orcid.org/0000-0002-5291-2875)
- Víctor Rossel (ORCID: https://orcid.org/0000-0002-4212-1148)
- Jing YU (ORCID: https://orcid.org/0009-0006-6182-7134)
- Muhammad Shahzeb Khan (ORCID: https://orcid.org/0000-0002-9089-8330)
- Ileana L. Piña (ORCID: https://orcid.org/0000-0002-4986-7129)
- Stefan D. Anker (ORCID: https://orcid.org/0000-0003-3331-7314)
- Carlos E. Ramos
- David Sim (ORCID: https://orcid.org/0000-0002-5136-9460)
- John R. Teerlink
- Offer Amir
- Kadhim Sulaiman (ORCID: https://orcid.org/0000-0001-5882-6102)
- Girish Chandrakant Rajadhyaksha
- James L. Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Nikhil Balankhe
- Vinayagam Palaniappan
- Aistė Štaraitė
Institutions
- Linköping University (SE)
- Almaty Management University (KZ)
- University of Nairobi (KE)
- Tufts Medical Center (US)
- Concord Hospital (US)
- San Francisco VA Medical Center (US)
- University of Lisbon (PT)
- Cairo University (EG)
- Thomas Jefferson University (US)
- University of Alberta (CA)
- University of Balamand (LB)
- Eduardo Mondlane University (MZ)
- University of the Witwatersrand (ZA)
- Johannes Gutenberg University Mainz (DE)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Vanderbilt University (US)
- Royal Brisbane and Women's Hospital (AU)
- Johannesburg Hospital (ZA)
- Hadassah Medical Center (IL)
- Hospital Israelita Albert Einstein (BR)
- Sree Chitra Thirunal Institute for Medical Sciences and Technology (IN)
- The Heart Research Institute (AU)
- Baylor University Medical Center (US)
- CARE Hospitals (IN)
- Population Health Research Institute (CA)
- The Ohio State University Wexner Medical Center (US)
- Kawaguchi Junior College (JP)
- University of Mississippi Medical Center (US)
- Topiwala National Medical College & BYL Nair Charitable Hospital (IN)
- British Heart Foundation (GB)
- Fukuoka International University (JP)
- Universidad de Antioquia (CO)
- Kuwait University (KW)
- Hospital Universitário de Santa Maria (BR)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Universitätsklinikum des Saarlandes (DE)
- Fundación Valle del Lili (CO)
- Mount Sinai Hospital (US)
- Instituto Nacional de Cardiologia (BR)
- Baim Institute for Clinical Research (US)
- Heart Hospital Baylor Plano (US)
- Social Service Sericulture Project Trust (IN)
- Lanzhou University Second Hospital (CN)
- German Centre for Cardiovascular Research (DE)
- National Taiwan University Hospital (TW)
- Royal Hospital (OM)
- Jena University Hospital (DE)
- Hypertension Institute (US)
- Noguchi Hospital (JP)
- National Heart Centre Singapore (SG)
- Hospital de Santa Maria (PT)
- Instituto Cardiovascular de Buenos Aires (AR)
- Heartland Alliance (US)
- Baylor Scott & White Health (US)
- Fu Wai Hospital (CN)
- Lanzhou University (CN)
- Icesi University (CO)
- University of Glasgow (GB)
- International University of Health and Welfare (JP)
- MedStar Health (US)
Publication Details
- Journal
- Global Cardiology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.4081/cardio.2025.70
- Citations
- 7
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 9.72
Funders
- Vanderbilt University
- McMaster University
- Heart Research Institute
- Universität des Saarlandes
- National Taiwan University Hospital
- National Taiwan University