Effects of pro-inflammatory cytokines induced by Porphyromonas gingivalis on cell cycle regulation in brain endothelial cells
P. gingivalis reduced cellular metabolism and induced early cell cycle arrest at the G0/G1 phase in mBECs cells. It also increased the pro-inflammatory response, which could be associated with cell death and possible senescence of brain endothelial cells. These results suggested a possible role for P. gingivalis in the pathogenesis of AD. Further studies are required to elucidate these underlying mechanisms.
Authors
- Yormaris Castillo (ORCID: https://orcid.org/0000-0002-8673-8449)
- Diana Marcela Buitrago (ORCID: https://orcid.org/0000-0001-6283-7656)
- Juana Buitrago (ORCID: https://orcid.org/0000-0002-7442-0847)
- Gloria Inés Lafaurie (ORCID: https://orcid.org/0000-0003-3986-0625)
- Antonio Rodrı́guez (ORCID: https://orcid.org/0000-0003-2455-6583)
Institutions
- Universidad El Bosque (CO)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1016/j.job.2025.100668
- Citations
- 2
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Universidad El Bosque