MANIFEST: Multiomic Platform for Cancer Immunotherapy
Immunotherapy has revolutionized survival outcomes for many patients diagnosed with cancer. However, biomarkers that can reliably distinguish treatment responders from nonresponders, predict potential life-threatening and life-changing drug-induced toxicities, or rationalize treatment choices are still lacking. In response to this unmet clinical need, we introduce Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity, a tumor type-agnostic platform to provide deep profiling of patients receiving immunotherapy that will enable integrative identification of biomarkers and discovery of novel targets using artificial intelligence and machine learning.
Authors
- Darren Treanor (ORCID: https://orcid.org/0000-0002-4579-484X)
- Corinne Faivre‐Finn (ORCID: https://orcid.org/0000-0001-5617-9781)
- Kairbaan Hodivala‐Dilke (ORCID: https://orcid.org/0000-0002-2859-749X)
- Javier A. Alfaro (ORCID: https://orcid.org/0000-0002-5553-6991)
- Bristi Basu (ORCID: https://orcid.org/0000-0002-3562-2868)
- Inês Sequeira (ORCID: https://orcid.org/0000-0003-3342-665X)
- Fiona Thistlethwaite (ORCID: https://orcid.org/0000-0002-4832-7008)
- Matthew P. Humphries
- Andrew Riddell (ORCID: https://orcid.org/0000-0002-9778-7983)
- Michael Hubank (ORCID: https://orcid.org/0000-0002-2901-0742)
- Santiago Zelenay (ORCID: https://orcid.org/0000-0002-6865-3978)
- Emma Nye (ORCID: https://orcid.org/0000-0001-9154-3526)
- Christopher R. S. Banerji (ORCID: https://orcid.org/0000-0002-4373-7657)
- Trevor A. Graham (ORCID: https://orcid.org/0000-0001-9582-1597)
- Benny Chain (ORCID: https://orcid.org/0000-0002-7417-3970)
- Caroline Dive (ORCID: https://orcid.org/0000-0002-1726-8850)
- Fiona Collinson (ORCID: https://orcid.org/0000-0001-6964-6406)
- Samra Turajlic (ORCID: https://orcid.org/0000-0001-8846-136X)
- Ananya Choudhury (ORCID: https://orcid.org/0000-0002-3561-6580)
- Trevor D. Lawley (ORCID: https://orcid.org/0000-0002-4805-621X)
- Manuel Salto‐Tellez (ORCID: https://orcid.org/0000-0001-8586-282X)
- Robert Anthony Huddart (ORCID: https://orcid.org/0000-0003-3604-1990)
- Christina Messiou (ORCID: https://orcid.org/0000-0002-0557-9379)
- Stefan N. Symeonides (ORCID: https://orcid.org/0000-0002-9892-9314)
- Andrew J.S. Furness (ORCID: https://orcid.org/0000-0002-2358-9730)
- Naveen Vasudev (ORCID: https://orcid.org/0000-0001-8470-7481)
- Gavin Kelly (ORCID: https://orcid.org/0000-0001-7219-560X)
- Anne Caroline Armstrong (ORCID: https://orcid.org/0000-0002-0774-7006)
- Will Ince (ORCID: https://orcid.org/0000-0002-2122-7760)
- George Kassiotis (ORCID: https://orcid.org/0000-0002-8457-2633)
- Bernadett Szabados (ORCID: https://orcid.org/0000-0002-8786-0032)
- Nicholas C. Turner (ORCID: https://orcid.org/0000-0001-8937-0873)
- Pippa Corrie (ORCID: https://orcid.org/0000-0003-4875-7021)
- Peter Schmid (ORCID: https://orcid.org/0000-0001-9817-5228)
- James O. Jones (ORCID: https://orcid.org/0000-0002-2194-4903)
- Brent O’Carrigan (ORCID: https://orcid.org/0000-0001-8187-6298)
- Juanita Suzanne Lopez (ORCID: https://orcid.org/0000-0001-8321-4212)
- Jennifer Hay (ORCID: https://orcid.org/0000-0001-9973-4992)
- Alicia Okines (ORCID: https://orcid.org/0000-0002-2068-2593)
- Xiao Fu (ORCID: https://orcid.org/0000-0002-8611-891X)
- Florent Moulière (ORCID: https://orcid.org/0000-0001-7043-0514)
- Paul C. Lorigan (ORCID: https://orcid.org/0000-0002-8875-2164)
- Alan A. Melcher (ORCID: https://orcid.org/0000-0002-2042-3380)
- Natalie Cook (ORCID: https://orcid.org/0000-0003-2606-1082)
- Dimitris Lagos (ORCID: https://orcid.org/0000-0003-0637-281X)
- Kathryn Simpson (ORCID: https://orcid.org/0000-0002-4386-0401)
- Karen Ambrose (ORCID: https://orcid.org/0000-0002-7109-3860)
- James Larkin (ORCID: https://orcid.org/0000-0001-5569-9523)
- Ajitha Rajan (ORCID: https://orcid.org/0000-0003-3765-3075)
- Jean‐Baptiste Cazier (ORCID: https://orcid.org/0000-0001-7581-9051)
- Grant Duncan Stewart (ORCID: https://orcid.org/0000-0003-3188-9140)
- Kok Haw Jonathan Lim (ORCID: https://orcid.org/0000-0002-6544-9218)
- Mark Stares (ORCID: https://orcid.org/0000-0002-5943-8440)
- Zayd Tippu (ORCID: https://orcid.org/0000-0002-3602-0770)
- Alexander Laird (ORCID: https://orcid.org/0000-0002-7296-025X)
- Peter E. Hall (ORCID: https://orcid.org/0000-0002-0057-5985)
- Véronique Birault
- Thomas B. Powles (ORCID: https://orcid.org/0000-0001-7760-4724)
- Rebecca Lee (ORCID: https://orcid.org/0000-0003-2540-2009)
- Ali Raza (ORCID: https://orcid.org/0000-0002-6575-8168)
- Pedro Oliveira (ORCID: https://orcid.org/0000-0002-0370-0788)
- David J. Harrison (ORCID: https://orcid.org/0000-0002-8834-0039)
- Tom Waddell (ORCID: https://orcid.org/0000-0001-5652-3829)
- Stuart McDonald
- Amy Strange
- J.D.B. De Bono
- Jyoti Choudhary (ORCID: https://orcid.org/0000-0001-8309-5954)
- Christopher Twelves
- James W. Fleming
- T. Chakraborty (ORCID: https://orcid.org/0009-0001-9826-7672)
- Brandon Witcher
Institutions
- Queen's University Belfast (GB)
- NHS Lothian (GB)
- Royal Marsden NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- Queen Mary University of London (GB)
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- Breast Cancer Now (GB)
- The Francis Crick Institute (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Wellcome Sanger Institute (GB)
- Edinburgh Cancer Research (GB)
- University of Manchester (GB)
- Cambridge School (PT)
- Bridge University (SS)
- Space Research Institute (UA)
- AMS (United Kingdom) (GB)
- Cancer Research UK Manchester Institute (GB)
- The Christie NHS Foundation Trust (GB)
- Genomics England (GB)
- Centre for Inflammation Research (GB)
- National Computing Centre (United Kingdom) (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0099
- Citations
- 5
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 4.03