ABO-Incompatible Renal Allograft in a Patient with Multiple Myeloma - A Case Report

Kidney impairment is common in multiple myeloma (MM), often progressing to end-stage kidney disease (ESKD). Although kidney transplantation was traditionally contraindicated, advances in chemotherapy and transplant management have made it a viable option for select MM cases with sustained hematological remission. A 55-year-old female with MM and ESKD achieved complete remission following six months of cyclophosphamide, bortezomib, and dexamethasone (CyBorD) therapy and continued on maintenance bortezomib. She declinined autologous stem cell transplantation, and underwent an ABO-incompatible renal transplant from her spouse. At 12 months post-transplant, graft function remained stable with no MM relapse.