Hormonal Whirlwinds to Emotional Echoes: The Deep-Rooted Impact of Polycystic Ovary Syndrome on Psyche and Well-Being

Background: Polycystic Ovarian Syndrome (PCOS) can be presented with physical and emotional consequences. Despite large research on the effects of hormonal imbalances on physical manifestations, psychological domains are still under a grey area. This study integrates clinical and psychosocial aspects of PCOS, leading to the development of comprehensive care approaches. Methods: 364 women aged between 18 and 35 were involved in a cross-sectional study at a tertiary care hospital. Participants were divided into four PCOS phenotype groups, diagnosed based on Rotterdam criteria, and a control group (n=240). Psychosocial domains were analysed using the HRQL-Health-Related Quality of Life questionnaire, biochemical and hormonal parameters were assessed. Correlation was found between hormones and various domains. Results: PCOS subjects exhibited high psychosocial stress across various domains, including emotional and fertility-related concerns. Hormonal imbalances were found to be differently associated with increased psychosocial distress, body image dissatisfaction, and menstruation-related challenges in various phenotypes (p<0.05). Moreover, financial burden and fear of developing malignancies were also linked to hormonal disturbances. Conclusion: Hormonal whirlwinds strongly affect the psychosocial aspects of PCOS subjects. Elucidating this link will pave a path for creating personalized treatment plans that can lead to physical and psychological well-being. By involving mental health support in the regular line of treatment, healthcare providers can create a better world for women suffering from PCOS.