Performance of routine surveillance diagnostics of external ventricular drain-associated infections in a critical care setting: a retrospective cohort study

In this study we evaluate current accepted EVDI surveillance methods in, to our knowledge, the largest cohort of paired samples to date. We find that current surveillance parameters cannot distinguish aseptic CNS inflammation from true EVDIs in an ICU setting. This contributes to a significant antibiotic overtreatment, with 25% of our entire cohort being unnecessarily initiated on broad-spectrum antibiotics, a number we expect can be generalized. We identify a large clinical problem with consequences on both a individual and population level, and recommend that future research focus on evaluating new techniques, such as fast bedside sequencing methods.