Comparative effectiveness of monotherapy vs. combination therapy for postoperative central nervous system infections in neurosurgical patients: a retrospective cohort study
The findings of this study suggest that, given concerns about antibiotic resistance and the varying complexities of infections, while SDT is effective in certain cases, VCT remains the preferred choice for complex CNSIs. This research provides important references for clinical practice, highlighting the need to consider multiple factors when selecting treatment options and advancing the understanding of treatment strategies for postoperative central nervous system infections.
Authors
- Jianhua Wang (ORCID: https://orcid.org/0000-0002-5276-5078)
- Shuang Yang (ORCID: https://orcid.org/0000-0001-5400-1234)
- Xihong Lin (ORCID: https://orcid.org/0000-0001-7067-7752)
- Qiuxia Shi
- Qiang Fu (ORCID: https://orcid.org/0000-0003-1916-1229)
- Wei Meng (ORCID: https://orcid.org/0000-0003-1268-9397)
- Yubo Wang (ORCID: https://orcid.org/0000-0002-2686-8946)
- Jie Wang (ORCID: https://orcid.org/0000-0001-8270-1035)
- Dongfeng Li (ORCID: https://orcid.org/0000-0003-2583-1727)
- Maojun Li (ORCID: https://orcid.org/0000-0001-7016-7963)
- Lifeng An (ORCID: https://orcid.org/0000-0002-4835-1817)
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Xinjiang Uygur Autonomous Region Uygur Medicine Hospital (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s12879-025-11031-0
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xinjiang Medical University