High rate of multi-drug resistant Escherichia coli isolated from patients with urinary tract infections in Ifakara-Tanzania: implications for empirical antibiotic treatment guidelines and stewardship programs
Nearly one-quarter of E. coli isolates causing UTIs were ESBL-E, predominantly ST167 harboring bla<sub>CTX-M-27</sub>. Notably, nitrofurantoin remained effective for uncomplicated UTIs, similarly, fosfomycin emerged as a viable alternative. However, ciprofloxacin, despite being recommended in local guidelines for complicated UTIs, showed no efficacy. The genetic similarity between human and environmental isolates underscores the critical need for a One Health approach to tackle antimicrobial resistance (AMR) in the region.
Authors
- Erin West (ORCID: https://orcid.org/0000-0001-7339-3819)
- Martin Rohacek (ORCID: https://orcid.org/0000-0002-0547-1923)
- Salomé N. Seiffert (ORCID: https://orcid.org/0000-0003-1639-131X)
- Baharak Babouee Flury (ORCID: https://orcid.org/0000-0001-8966-5882)
- Magreth Erick Macha (ORCID: https://orcid.org/0000-0001-8715-8983)
- Philipp Köhler (ORCID: https://orcid.org/0000-0003-0427-8934)
- Weihong Qi (ORCID: https://orcid.org/0000-0001-8581-908X)
- Anja Bösch
- Sabine Haller
- Honorathy Urassa
Institutions
- Ifakara Health Institute (TZ)
- University of Bern (CH)
- Swiss Tropical and Public Health Institute (CH)
- University of Zurich (CH)
- University of St.Gallen (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- ETH Zurich (CH)
- St. Francis Referral Hospital (TZ)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s13756-025-01557-y
- Citations
- 1
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Australian Government
- Swiss Society for Infectious Diseases