Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression
Our study suggests that KAT2B-mediated acetylation of AIM2 can suppress the stimulation of the AKT/Wnt/β-catenin axis, consequently inhibiting breast carcinoma progression.
Authors
- Shengchun Liu (ORCID: https://orcid.org/0000-0002-9933-3643)
- Lingcheng Wang (ORCID: https://orcid.org/0000-0002-8380-8165)
- Yaqiong Li (ORCID: https://orcid.org/0000-0002-2151-6618)
- Wei Huang (ORCID: https://orcid.org/0000-0002-4217-1567)
- Wei Wei Wangb
Institutions
- Hubei University of Medicine (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s13072-025-00591-9
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05