The Role of NMDA and NK1 Receptor Signaling in Spine Surgery–induced Central Sensitization
The findings highlight the role of NMDA and NK1 receptor stimulation/upregulation in central sensitization caused by spine surgery. Targeting these receptors presurgically presents a promising strategy to prevent hypersensitivity development and improve postoperative pain management for spine surgery patients.
Authors
- Jun‐Ho La (ORCID: https://orcid.org/0000-0003-4306-0305)
- Grace Liu (ORCID: https://orcid.org/0000-0003-0159-6750)
- Asia Eter
- Satoshi Yamamoto (ORCID: https://orcid.org/0000-0001-9205-1144)
- J. M. Chung
- Amber Nguyen
- Jaden Fang
Institutions
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Spine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1097/brs.0000000000005382
- Citations
- 6
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 12.04