Cutibacterium acnes lysate improves cellular response against Candida albicans, Escherichia coli and Gardnerella vaginalis in an in vitro model of vaginal infection
Overall, the results shown here point to the possible role of BL in priming epithelial and phagocytic cells and to improve their response against bacterial and fungal pathogens. These data indicate that the use of this (and, in future, other bacterial lysates) may provide a promising novel approach to handle lower genital tract infections through the reinforcement of local immunity.
Authors
- Francesco De Seta (ORCID: https://orcid.org/0000-0003-1611-0813)
- Francesco Ricchi
- Eva Pericolini (ORCID: https://orcid.org/0000-0002-5299-8197)
- Natalia Pedretti (ORCID: https://orcid.org/0009-0007-2452-0501)
- Samyr Kenno (ORCID: https://orcid.org/0000-0002-9448-7344)
- Andrea Ardizzoni (ORCID: https://orcid.org/0000-0001-9845-7399)
- Giulia Brenna
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Trieste (IT)
- Vita-Salute San Raffaele University (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fcimb.2025.1578831
- Citations
- 5
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 5.92
Funders
- Università Degli Studi di Modena e Reggio Emila