RNA hybrid-capture next-generation sequencing has high sensitivity in identifying known and less characterized oncogenic and likely oncogenic NTRK fusions in a real-world standard-of-care setting
The high prevalence of oncogenic and likely oncogenic <i>NTRK</i> fusions detected in our analysis suggests that RNA hybrid-capture-based sequencing for fusion detection is a highly sensitive method for identifying clinically meaningful known and novel <i>NTRK</i> fusions, which may be missed with other detection methods, directly impacting therapeutic options and patient outcomes.
Authors
- Pratheesh Sathyan
- Taylor J. Jensen (ORCID: https://orcid.org/0000-0002-7206-7656)
- Shakti Ramkissoon
- Eric A. Severson (ORCID: https://orcid.org/0000-0003-4394-2412)
- Erica Schnettler
- Zachary D. Wallen (ORCID: https://orcid.org/0000-0002-2278-7348)
- Marcia Eisenberg
- Alison Roos
- Marni Brisson Tierno (ORCID: https://orcid.org/0000-0002-4159-0823)
- Sarabjot Pabla (ORCID: https://orcid.org/0000-0002-7746-9144)
- Rebecca A. Previs (ORCID: https://orcid.org/0000-0001-8087-9120)
- Brian Caveney
- Michelle Green (ORCID: https://orcid.org/0000-0002-6055-4342)
- Stephanie Hastings
- Kobina Amoah
Institutions
- Illumina (United States) (US)
- LabCorp (United States) (US)
- Wake Forest University (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fgene.2025.1550706
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87