Metabolomic insights into amino acid signatures and pathways associated with osteoporosis in Iranian elderly population
Osteoporosis is associated with altered serum amino acids levels in both men and women. The condition is associated with several altered metabolic pathways, with "phenylalanine, tyrosine, and tryptophan biosynthesis" being the most important one. These metabolite signatures and pathways could be targeted for the prevention and management of osteoporosis in older adults.
Authors
- Bagher Larijani (ORCID: https://orcid.org/0000-0001-5386-7597)
- Hojat Dehghanbanadaki (ORCID: https://orcid.org/0000-0003-1057-0309)
- Noushin Fahimfar (ORCID: https://orcid.org/0000-0001-6205-9794)
- Fatemeh Bandarian
- Farideh Razi (ORCID: https://orcid.org/0000-0003-2350-9574)
- Afshin Ostovar (ORCID: https://orcid.org/0000-0001-8670-5797)
- Iraj Nabipour (ORCID: https://orcid.org/0000-0002-1785-0883)
- Ziba Majidi (ORCID: https://orcid.org/0009-0005-0930-9973)
- Akbar Soltani (ORCID: https://orcid.org/0000-0003-3973-5744)
- Niloufar Najjar
- Gita Shafiee (ORCID: https://orcid.org/0000-0003-3441-3578)
- Mostafa Rezaei-Tavirani (ORCID: https://orcid.org/0000-0002-5284-3179)
- Patricia Khashayar
Institutions
- University of Minnesota (US)
- Biotechnology Research Center (IR)
- Bushehr University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fmed.2025.1515449
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03