Dynamics of neutrophil phenotype and function in sickle cell disease
While neutrophil phenotype in SCD patients differed from non-matched controls, in contrast to earlier studies, the differences in neutrophil phenotype between SCD patients and ethnicity-matched controls were modest. <i>In vitro</i> neutrophil adhesion was higher in SCD patients than in ethnicity-matched and non-matched controls. Potential explanations for the discrepancies between earlier findings and our study are the large variation in neutrophil phenotypes between individuals, methodological variability between studies and differences in the time interval between blood sample collection and the measurements.
Authors
- Aafke E. Gaartman (ORCID: https://orcid.org/0000-0002-7534-5084)
- Rob van Zwieten (ORCID: https://orcid.org/0000-0002-9673-2083)
- Anton T. J. Tool (ORCID: https://orcid.org/0000-0002-8227-1888)
- Taco W. Kuijpers (ORCID: https://orcid.org/0000-0002-7421-3370)
- Boukje M. Beuger
- Martijn Veldthuis
- Erfan Nur (ORCID: https://orcid.org/0000-0002-7069-930X)
- Robin van Bruggen (ORCID: https://orcid.org/0000-0002-1676-0720)
- Lydian A. de Ligt (ORCID: https://orcid.org/0009-0003-2934-4739)
- Bart J. Biemond (ORCID: https://orcid.org/0000-0002-4426-5743)
Institutions
- Sanquin (NL)
- Emma Kinderziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1591283
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Amsterdam University Medical Centers