Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice
Our study reveals that BITC may be a promising therapeutic option for IPF and other age-related disease that progress with the accumulation of senescent fibroblasts.
Authors
- Qinhui Hou
- Zhenshun Cheng
- Fan Yang (ORCID: https://orcid.org/0009-0008-5468-4782)
- Meiting Peng
- Ying Liu
- Rui Wang (ORCID: https://orcid.org/0000-0003-3825-3620)
- Lu Yu (ORCID: https://orcid.org/0009-0007-9449-8274)
- Yuan Liu
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fphar.2025.1506518
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University