Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

This PBPK modeling platform provides a robust tool for identifying and mitigating DDIs in the pre- and early post-HSCT phases. By enabling the optimization of treatment regimens, this model serves as a valuable tool for improving drug safety and therapeutic outcomes for patients with HSCT.

Authors

Jing Yang (ORCID: https://orcid.org/0000-0002-2113-6578)
Peile Wang (ORCID: https://orcid.org/0000-0002-3264-4092)
Jingli Lü (ORCID: https://orcid.org/0000-0001-7411-1430)

Institutions

Zhengzhou University (CN)
First Affiliated Hospital of Zhengzhou University (CN)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2025-05-02
DOI: https://doi.org/10.3389/fphar.2025.1578643
Citations: 1
Primary Topic: Antibiotics Pharmacokinetics and Efficacy
Type: article
Field-Weighted Citation Impact: 1.39

Funders

Foundation of Henan Educational Committee

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article

Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

Jing Yang, Peile Wang, Jingli Lü

May 2, 2025

1 citations

Frontiers in Pharmacology

Antibiotics Pharmacokinetics and Efficacy

1.39

article

Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

Jing Yang, Peile Wang, Jingli Lü

May 2, 2025article en

1 citations

Abstract

This PBPK modeling platform provides a robust tool for identifying and mitigating DDIs in the pre- and early post-HSCT phases. By enabling the optimization of treatment regimens, this model serves as a valuable tool for improving drug safety and therapeutic outcomes for patients with HSCT.

Frontiers in PharmacologyVol. 16

Zhengzhou University (CN), First Affiliated Hospital of Zhengzhou University (CN)

Foundation of Henan Educational Committee

Good health and well-being

Openalex Percentile: Top 21%

Antibiotics Pharmacokinetics and Efficacy

1.39

DOI Open Access PDF OpenAlex

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Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages — Jing Yang, Peile Wang, et al. · Frontiers in Pharmacology (2025) | TGRS Research Map | TGRS