A pilot study of gut mucosal and faecal microbiota in rectal cancer: associations with histological response and adverse events following preoperative chemoradiotherapy
This study suggests an association between the gut microbiota, the therapeutic effectiveness of CRT and the occurrence of treatment-associated diarrhoea in rectal cancer. These results indicate the potential for predicting treatment efficacy and adverse events based on the microbiota composition.
Authors
- Soichiro Ishihara (ORCID: https://orcid.org/0000-0003-0543-0045)
- Yuichi Tachikawa (ORCID: https://orcid.org/0000-0002-8052-6867)
- Koji Murono (ORCID: https://orcid.org/0000-0002-4184-5443)
- Masashi Ohno (ORCID: https://orcid.org/0000-0003-3505-7835)
- Takamitsu Tsukahara (ORCID: https://orcid.org/0000-0002-3902-5956)
- Shin Murai (ORCID: https://orcid.org/0000-0001-7868-0104)
- Kazuhito Sasaki (ORCID: https://orcid.org/0000-0003-3569-6944)
- Ryo Inoüe (ORCID: https://orcid.org/0000-0002-7233-366X)
- Yuriko Inagaki
- Yuichiro Yokoyama (ORCID: https://orcid.org/0000-0003-4578-4454)
- Shinya Abe (ORCID: https://orcid.org/0000-0002-2432-3141)
- Shigenobu Emoto (ORCID: https://orcid.org/0000-0002-6146-9385)
- Hiroaki Nozawa (ORCID: https://orcid.org/0000-0002-7891-5986)
- Yuzo Nagai
- Satoshi Okada (ORCID: https://orcid.org/0000-0003-1514-3031)
- Kensuke Kaneko (ORCID: https://orcid.org/0000-0003-0510-4602)
- Takahide Shinagawa (ORCID: https://orcid.org/0000-0003-3790-7047)
- Akira Andoh
- Kai Ohashi
Institutions
- Setsunan University (JP)
- Shiga University of Medical Science (JP)
- Institute of Nutrition and Pathology (Japan) (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Colorectal Disease
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/codi.70106
- Citations
- 2
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Japan Society for the Promotion of Science