Anti-PD-1 antibody enhances homeostatic proliferation–induced antitumor immunity during lymphopenia recovery
These findings indicate that the PD-1/PD-L1 axis plays a critical role in immune tolerance during homeostatic proliferation. Anti-PD-1 therapy may enhance antitumor immunity during lymphopenia recovery after chemotherapy or radiotherapy, offering a potential strategy to sustain T-cell-mediated tumor control.
Authors
- Qing Lin (ORCID: https://orcid.org/0000-0002-8761-9468)
- Zike Yang (ORCID: https://orcid.org/0000-0003-1785-8225)
- Ying Zhu (ORCID: https://orcid.org/0000-0002-2534-290X)
- Yahui Liu (ORCID: https://orcid.org/0000-0002-4018-5404)
- Qian Wang (ORCID: https://orcid.org/0000-0002-2149-384X)
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1563894
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Southern Medical University
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund