B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort
CS and vaping additively enhance B-cell activation, most notably in dual-users. CS and vaping are significantly associated to multiple alterations in B-cell function including increased class switching, clonal expansion, and a shift towards IgA-producing cell populations. These changes could be relevant to response to infection and vaccinations and merit further study.
Authors
- Gregory L. Kinney (ORCID: https://orcid.org/0000-0002-5218-4986)
- Christopher Vollmers (ORCID: https://orcid.org/0000-0002-7626-6222)
- Maor Sauler (ORCID: https://orcid.org/0000-0001-5240-7978)
- Michael H. Cho (ORCID: https://orcid.org/0000-0002-4907-1657)
- Edwin K. Silverman (ORCID: https://orcid.org/0000-0002-3641-3822)
- Francesca Polverino (ORCID: https://orcid.org/0000-0001-9686-5698)
- Jeffrey L. Curtis (ORCID: https://orcid.org/0000-0001-5191-4847)
- Adel Boueiz (ORCID: https://orcid.org/0000-0003-1638-8575)
- Min Hyung Ryu (ORCID: https://orcid.org/0000-0003-3071-7363)
- Craig P. Hersh (ORCID: https://orcid.org/0000-0002-1342-4334)
- Zhonghui Xu (ORCID: https://orcid.org/0000-0002-6469-9178)
- Laura E. Crotty Alexander (ORCID: https://orcid.org/0000-0002-5091-2660)
- Matthew Moll (ORCID: https://orcid.org/0000-0002-0683-0975)
- Peter J. Castaldi
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Colorado School of Public Health (US)
- Baylor College of Medicine (US)
- University of California, Santa Cruz (US)
- University of Michigan (US)
- VA Boston Healthcare System (US)
- University of California System (US)
- Yale University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- VA Ann Arbor Healthcare System (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1508786
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institute for Health and Care Research
- Genentech
- Canadian Institutes of Health Research
- National Heart, Lung, and Blood Institute