Japanese encephalitis virus-associated human microglia induce cell death of human microvascular endothelial cells in receptor-independent infection
Overall, our findings demonstrate that human microvascular endothelial cells supply virus propagation and Japanese encephalitis virus-associated microglia greatly contribute to endothelial cell death, an important component of the blood brain barrier integrity. Importantly, Tumour Necrosis Factor-related apoptosis inducing ligand and receptors represents a promising therapeutic target preventing microvascular endothelial cell death after neuroinvasion.
Authors
- Nils Lannes (ORCID: https://orcid.org/0000-0002-2926-6182)
- Isabelle Fellay
- Luis Filgueira (ORCID: https://orcid.org/0000-0002-2266-6650)
- Alexey Larionov (ORCID: https://orcid.org/0000-0001-6902-8878)
- Pauline Blanc
- Léa Schlunke (ORCID: https://orcid.org/0009-0007-1394-0842)
Institutions
- University of Fribourg (CH)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fcimb.2025.1580958
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Université de Fribourg
- Faculté des Sciences et de Médecine, Université de Fribourg