Clinical characteristics and risk factors of chronic critical illness in children with sepsis
CCI in pediatric sepsis is associated with underlying respiratory diseases, trauma, elevated pSOFA scores, surgical procedures, prolonged mechanical ventilation and secondary infections. These factors contribute to extended hospital stays, elevated secondary infection rates, and poor clinical outcomes. The persistence of pro-inflammatory mediators and subsequent immunosuppression may underlie the development of CCI in this population.
Authors
- Na Zang (ORCID: https://orcid.org/0000-0001-6658-6700)
- Ying Yang (ORCID: https://orcid.org/0000-0003-2294-7249)
- Cong Liu (ORCID: https://orcid.org/0000-0003-2217-8355)
- En Mei Liu
- Lin Yang (ORCID: https://orcid.org/0000-0001-5049-7519)
- Li Tan (ORCID: https://orcid.org/0000-0002-3068-9078)
- K. Pu
Institutions
- China International Science and Technology Cooperation (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fped.2025.1561044
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Centre Scientifique et Technique du Bâtiment