NLRP3 inflammasome activation by turbulent shear stress drives right ventricular outflow tract fibrosis in pulmonary regurgitation
PR-induced TSS in the RVOT activates the NLRP3 inflammasome in cardiomyocytes, triggering inflammation and fibrosis that drive regional RV dysfunction. Quantifying TSS may serve as an early biomarker for subclinical RV injury, while targeting NLRP3 signaling could offer a therapeutic strategy to mitigate fibrosis in PR patients.
Authors
- Qiang Fan
- Yingying Ling (ORCID: https://orcid.org/0009-0006-2768-2410)
- Yabo Wang (ORCID: https://orcid.org/0000-0001-8925-5277)
- Qi An (ORCID: https://orcid.org/0009-0008-3520-7833)
- Dongyong Zhu
Institutions
- Union Hospital (HK)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fcvm.2025.1546581
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan University
- Southwest Medical University
- West China Hospital, Sichuan University