Gen-miR-5 derived from Gentianella acuta inhibits PFKP to prevent fibroblast activation and alleviate myocardial fibrosis
In conclusion, we have elucidated for the first time the pharmacological effects of Gen-miR-5, derived from <i>G. acuta</i>, in inhibiting MF. Gen-miR-5 exerts its cardioprotective effects by targeting and inhibiting the expression of the key glycolytic enzyme PFKP, induced by Ang II, regulating lactate metabolism in fibroblast, and preventing the transformation of fibroblasts into myofibroblasts, ultimately alleviating MF. This study demonstrates that Gen-miR-5 is a potential therapeutic agent for improving cardiac remodeling.
Authors
- Aiying Li (ORCID: https://orcid.org/0000-0001-7779-1814)
- Zhenyu Du (ORCID: https://orcid.org/0000-0001-8603-2078)
- Hongyao Ge
- Gaoshan Yang
- Weizhe Liu (ORCID: https://orcid.org/0000-0003-3762-7344)
- Letian Wang (ORCID: https://orcid.org/0009-0000-0640-301X)
- Junyang Li (ORCID: https://orcid.org/0000-0003-0089-6962)
Institutions
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Hebei University of Chinese Medicine (CN)
- Hebei Science and Technology Department (CN)
- Hebei Institute of Physical Education (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fphar.2025.1578877
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Hebei University
- Hebei University of Chinese Medicine