Combined use of olfactory mucosal mesenchymal stem cells conditioned medium and neural guide conduits promotes nerve regeneration in an ovine model
These findings highlight the complexity of peripheral nerve regeneration in challenging surgical scenarios and underscore the translational potential of biomaterials and cell conditioned medium-based therapies. However, the observed irregularities emphasize the need for further research in complex animal models before application in real clinical cases. Such studies are essential to refine therapeutic strategies, address inconsistencies, and establish cell conditioned medium as a viable tool in peripheral nerve regeneration and repair.
Authors
- Patrícia Sousa (ORCID: https://orcid.org/0000-0003-2531-3196)
- Isabel Pires (ORCID: https://orcid.org/0000-0001-6330-4560)
- Bruna Lopes (ORCID: https://orcid.org/0000-0002-8168-2415)
- Carla Mendonça (ORCID: https://orcid.org/0000-0002-6321-9996)
- Filipa João (ORCID: https://orcid.org/0000-0002-8976-0932)
- André Coelho (ORCID: https://orcid.org/0000-0002-6934-9935)
- Rui Alvites (ORCID: https://orcid.org/0000-0003-1945-6377)
- Nuno M. Alves (ORCID: https://orcid.org/0000-0002-5016-0868)
- Justina Prada (ORCID: https://orcid.org/0000-0002-3902-5374)
- Ana Lúcia Luís (ORCID: https://orcid.org/0000-0003-2328-7174)
- Stefania Raimondo (ORCID: https://orcid.org/0000-0002-8907-473X)
- Ana Catarina Sousa (ORCID: https://orcid.org/0000-0002-8800-2195)
- Luís Atayde (ORCID: https://orcid.org/0000-0001-7668-3897)
- Alícia Moreira (ORCID: https://orcid.org/0000-0002-1347-8789)
- Alexandra Rêma (ORCID: https://orcid.org/0000-0003-4319-2404)
- Bruna Silva (ORCID: https://orcid.org/0000-0001-7660-9443)
- Maria José Simões (ORCID: https://orcid.org/0000-0001-9810-1683)
- Ana Colette Maurício (ORCID: https://orcid.org/0000-0002-0018-9363)
- Miriam Metafune
- Francesca Bertone
Institutions
- University of Trás-os-Montes and Alto Douro (PT)
- Instituto Politécnico de Leiria (PT)
- Universidade do Porto (PT)
- Cooperativa de Ensino Superior Politécnico e Universitário (PT)
- Neuroscience Institute (IT)
- University of Turin (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fcell.2025.1598736
- Citations
- 1
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.91