Supramolecular nanofibers of natural asiaticoside for self-supporting gelation and enhanced transdermal delivery
This work pioneers the use of AS as a natural supramolecular gelator, addressing its bioavailability challenges through nanostructured self-assembly. The hydrogel's dual functionality (pH-responsive gelation and enhanced permeation) offers a sustainable platform for the transdermal delivery of hydrophobic phytochemicals, bridging phytochemistry and nanobiotechnology. This strategy expands the application of plant-derived saponins in advanced drug delivery systems.
Authors
- Shuang Tian (ORCID: https://orcid.org/0000-0002-9588-9388)
- Wenping Wang (ORCID: https://orcid.org/0009-0009-6115-3880)
- Rui Zhu
- Jiao Wang (ORCID: https://orcid.org/0000-0001-5120-8643)
- Wen Luo (ORCID: https://orcid.org/0000-0003-4250-6168)
- Chen Liu (ORCID: https://orcid.org/0009-0003-0430-6146)
- Hongyun Li (ORCID: https://orcid.org/0000-0003-3332-3132)
- Xixi Hu (ORCID: https://orcid.org/0000-0001-6392-476X)
- Jian Yao (ORCID: https://orcid.org/0000-0002-4716-5270)
- Yiwen Dai
- Yuhua Ma
Institutions
- Qinghai University for Nationalities (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fbioe.2025.1589865
- Citations
- 3
- Primary Topic
- Lipid Membrane Structure and Behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Science and Technology Department