Decrease in low-density lipoprotein cholesterol is associated with an increased risk of mortality in patients with diabetes mellitus
A total of 1,329,982 patients were included, including 532,260 patients who did not receive statin therapy (non-statin users). Compared to statin users, non-statin users had a higher incidence of all-cause mortality (incidence rate 13.9-16.4 per 1,000 person-years) and SCA (1.6-1.9). Among non-statin users, patients with decreased LDL-cholesterol had the highest risk of all-cause mortality (adjusted hazard ratio 1.26, 95% confidence interval 1.21-1.31, <i>P</i> < 0.001) and SCA (1.21, 1.10-1.34, <i>P</i> < 0.001). Thus, in patients with diabetes mellitus not receiving statin therapy, a decrease in LDL-cholesterol may be a surrogate marker for all-cause mortality and SCA.
Authors
- Hyoung Seok Lee
- Joo Hee Jeong (ORCID: https://orcid.org/0000-0001-8308-0197)
- Chang-Ok Seo
- Jaemin Shim (ORCID: https://orcid.org/0000-0001-8251-1522)
- Seung‐Young Roh (ORCID: https://orcid.org/0000-0002-0854-9079)
- Kyungdo Han (ORCID: https://orcid.org/0000-0002-6096-1263)
- Young-Hoon Kim (ORCID: https://orcid.org/0000-0003-4656-0188)
- Jong-Ιl Choi (ORCID: https://orcid.org/0000-0001-5272-0905)
- Yeji Kim (ORCID: https://orcid.org/0009-0005-4185-9342)
- Yun Gi Kim (ORCID: https://orcid.org/0000-0003-2905-6609)
Institutions
- Soongsil University (KR)
- Korea University (KR)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fcvm.2025.1549517
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Korea University Anam Hospital