RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity
These findings indicate that the inhibition of RAC2 in tumor cells substantially enhances their susceptibility to NK cell-mediated cytotoxicity, thereby providing a potential therapeutic target for optimizing NK cell therapy.
Authors
- Xiaojun Xia (ORCID: https://orcid.org/0000-0003-4444-7472)
- Zining Wang (ORCID: https://orcid.org/0000-0002-0087-2453)
- Huan Jin (ORCID: https://orcid.org/0000-0003-0721-8283)
- Lei Cui (ORCID: https://orcid.org/0000-0003-4365-5173)
- Zixuan Guo (ORCID: https://orcid.org/0009-0007-1901-5893)
- Tiantian Wang (ORCID: https://orcid.org/0000-0002-1112-7678)
- Xiaojuan Wang (ORCID: https://orcid.org/0000-0002-3490-963X)
- Heping Li (ORCID: https://orcid.org/0000-0002-4281-2475)
- Li Lin (ORCID: https://orcid.org/0000-0003-2783-1114)
- Feifei Xu
- Hui Guo (ORCID: https://orcid.org/0000-0001-6769-1772)
- C. Xie (ORCID: https://orcid.org/0000-0002-9906-3081)
- Jie Hu (ORCID: https://orcid.org/0000-0003-2605-7120)
- Huanling Zhang (ORCID: https://orcid.org/0000-0002-1762-6136)
- Ruhui Yao
- Yanxun Lin
- Yongxiang Liu
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2024-010931
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China