Vascular Smooth Muscle Cell Migration and P70S6K: Key Players in Intimal Hyperplasia Development
VSMC migration, rather than proliferation, mirrors PAP-1 and EV effects on IH development in vessels. Critically, we identify VSMC P70S6K phosphorylation as a surrogate marker for IH progression. The nonmonotonic responses of P70S6K activation to pathway blockers suggest the existence of a crosstalk element functioning as an exclusive NOR logic gate providing new insights for IH prevention strategies.
Authors
- José R. López‐López (ORCID: https://orcid.org/0000-0002-3870-421X)
- M. Teresa Pérez‐García (ORCID: https://orcid.org/0000-0001-8540-8117)
- Sara Moreno‐Estar (ORCID: https://orcid.org/0000-0001-8047-2865)
- Pilar Cidad (ORCID: https://orcid.org/0000-0002-6338-7738)
- A.M. Portillo (ORCID: https://orcid.org/0000-0003-3686-5033)
- Marycarmen Arévalo‐Martínez (ORCID: https://orcid.org/0000-0002-3162-4807)
- Esperanza Alonso
- Marcos Sacristan‐Moraleda (ORCID: https://orcid.org/0000-0002-2066-5160)
Institutions
- Universidad de Valladolid (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
- Institute of Mathematical Sciences (ES)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1161/jaha.124.038358
- Citations
- 1
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81