Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats
The misalignment between maternal feeding time and the biological clock during pregnancy disrupts the balance of the gut microbiota and peripheral rhythms. The impaired intestinal and placental barriers allow LPS from the gut to infiltrate the maternal hippocampus and fetal brain, increasing inflammation and impacting both maternal and fetal brain health.
Authors
- Yucun Niu (ORCID: https://orcid.org/0000-0002-4879-6664)
- Xiangju Kong
- Xinyue Wang (ORCID: https://orcid.org/0000-0001-6990-783X)
- Meiwen An (ORCID: https://orcid.org/0000-0001-7114-6902)
- Yibo Ding (ORCID: https://orcid.org/0000-0002-2544-3882)
- Yue Guan
- Xuan Zhu
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s12974-025-03447-x
- Citations
- 3
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China