Retroviral foamy virus gag induces parkin-dependent mitophagy
Our data suggested that PFV can induce mitophagy and Gag induces Parkin-dependent mitophagy by upregulating Rab5a. These findings not only enhance a better understanding of the foamy virus infection mechanisms but also provide critical insights into novel virus-host cell interactions.
Authors
- Qian Xu (ORCID: https://orcid.org/0000-0002-7623-217X)
- Jun Yin
- Jun Yan (ORCID: https://orcid.org/0000-0002-9133-0034)
- Yingcheng Zheng (ORCID: https://orcid.org/0000-0002-1246-8749)
- Song Han (ORCID: https://orcid.org/0000-0003-4659-4388)
- Yinglian Tang
- Shanshan Xu (ORCID: https://orcid.org/0000-0002-1750-4171)
- Shanshan Wang (ORCID: https://orcid.org/0009-0000-7215-6555)
- Xiong Chen (ORCID: https://orcid.org/0000-0001-8217-5362)
- Luo Liu (ORCID: https://orcid.org/0000-0002-3542-8213)
- Xiaohua He
- Tongtong Du
- Wanhong Liu (ORCID: https://orcid.org/0000-0003-3271-4342)
- Biwen Peng
- Jin Wu (ORCID: https://orcid.org/0000-0001-6603-9491)
Institutions
- Guiyang Medical University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Children's Hospital (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Retrovirology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s12977-025-00664-3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wuhan University
- Guizhou Medical University
- Fundamental Research Funds for the Central Universities