IVIG Resistance in Kawasaki Disease: Clinical and Laboratory Risk Factors and the Potential Role of Administration Timing

IVIG timing is a key factor in IVIG resistance. Our data suggest a lower resistance rate when IVIG is administered on the seventh and eighth day of initial fever. However, the clinical implications of delaying treatment are uncertain, and early IVIG administration remains essential to prevent cardiovascular complications. Further research is needed to validate these findings and to guide clinical practice.

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Publication Details

Journal
Journal of Inflammation Research
Published
2025-05-01
DOI
https://doi.org/10.2147/jir.s513963
Primary Topic
Kawasaki Disease and Coronary Complications
Type
article
Field-Weighted Citation Impact
0.00

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article

IVIG Resistance in Kawasaki Disease: Clinical and Laboratory Risk Factors and the Potential Role of Administration Timing

Feifei Si, Yanfeng Yang, Qijian Yi, Siqi Feng et al.
Journal of Inflammation Research
Kawasaki Disease and Coronary Complications
article

IVIG Resistance in Kawasaki Disease: Clinical and Laboratory Risk Factors and the Potential Role of Administration Timing

Feifei Si, Yanfeng Yang, Qijian Yi, Siqi Feng, Wenliang Jiang, Fengchuan Jing, Ya Su, Yan‐Xia Xu, Cong Li, Bin Li, Zhenli Cheng, Zhongyou Tan, Xue Zhou, Dong Liu, Ouyang Chen, Yue Peng
article en

Abstract

IVIG timing is a key factor in IVIG resistance. Our data suggest a lower resistance rate when IVIG is administered on the seventh and eighth day of initial fever. However, the clinical implications of delaying treatment are uncertain, and early IVIG administration remains essential to prevent cardiovascular complications. Further research is needed to validate these findings and to guide clinical practice.

Journal of Inflammation ResearchVol. Volume 18
National Health and Family Planning Commission (CN), Affiliated Hospital of Southwest Medical University (CN), Chengdu Women's and Children's Central Hospital (CN), Kunming Children's Hospital (CN), Chongqing Three Gorges Central Hospital (CN), Chongqing Population and Family Planning Science and Technology Research Institute (CN), Guizhou Provincial People's Hospital (CN), Children's Hospital of Chongqing Medical University (CN), Chongqing Dazu District People's Hospital (CN), Chongqing Three Gorges University (CN), Chongqing Medical University (CN)
Chongqing University, Chongqing Medical University
Good health and well-being
Openalex Percentile: Top 84%
Kawasaki Disease and Coronary Complications
DOIOpen Access PDFOpenAlex
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