USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer
The study highlights the USP14/BAG4/PRKN axis as a critical pathway in CRC (MSI-H), suggesting that targeting USP14 could inhibit tumor progression and improve chemotherapeutic outcomes. These findings underscore the importance of ubiquitination and mitophagy in cancer biology, indicating a potential therapeutic target for MSI-H CRC.
Authors
- Cheng‐Ping Yu (ORCID: https://orcid.org/0000-0002-0693-5056)
- Gengchen Xie
- Zhijie Yin (ORCID: https://orcid.org/0000-0001-5097-6245)
- Qing Lv (ORCID: https://orcid.org/0000-0002-8063-3451)
- Zhiyong Wang (ORCID: https://orcid.org/0000-0002-0031-9447)
- Kaixiong Tao (ORCID: https://orcid.org/0000-0002-1193-2458)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1186/s10020-025-01182-w
- Citations
- 3
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.42