<scp>3D</scp> virtual biopsy of in vivo <scp>pH</scp> and metabolism using <scp>PRESS</scp> and semi‐<scp>LASER MRS</scp> of hyperpolarized <scp><sup>13</sup>C</scp> nuclei
For the first time, we show hyperpolarized MRS using multi-voxel PRESS and semi-LASER sequences for hyperpolarized <sup>13</sup>C-labeled molecules. By implementing a semi-LASER sequence using adiabatic full passage refocusing pulses, RF saturation was reduced. Semi-LASER allows flexible overlapping of voxel refocusing planes, while for PRESS, signal from these regions is attenuated.
Authors
- Jason G. Skinner (ORCID: https://orcid.org/0000-0003-1260-8163)
- Rickmer Braren
- Irina Heid
- Wolfgang Gottwald (ORCID: https://orcid.org/0009-0002-3779-7087)
- Geoffrey J. Topping
- Sebastian Bauer (ORCID: https://orcid.org/0000-0003-4328-195X)
- Martin Grashei (ORCID: https://orcid.org/0000-0002-5019-9359)
- Sandra Sühnel
- Luca Nagel (ORCID: https://orcid.org/0000-0002-5530-6264)
- Franz Schilling (ORCID: https://orcid.org/0000-0001-5239-4628)
- Nadine Setzer
- Florian Gaksch
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- TUM Klinikum (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/mrm.30544
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung