Immunomodulatory effects of intratumoral cowpea mosaic virus and calreticulin nanoparticles in canine tumors: early results
Our findings suggest that CPMV and CRT-NP, which activate distinct immunologic pathways, safely modulate the TME contributing to disease stabilization in spontaneous canine cancers. These results support the need for larger-scale trials to address current limitations, differentiate tumor-agnostic versus treatment-specific effects, and evaluate long-term clinical outcomes, including overall survival (OS).
Authors
- Deepan Kishore (ORCID: https://orcid.org/0000-0001-8251-431X)
- J. Schrader (ORCID: https://orcid.org/0000-0002-1298-9755)
- Nicole F. Steinmetz (ORCID: https://orcid.org/0000-0002-0130-0481)
- Akansha Singh (ORCID: https://orcid.org/0000-0001-9101-4157)
- Steven Fiering (ORCID: https://orcid.org/0000-0003-0624-974X)
- Ashish Ranjan (ORCID: https://orcid.org/0000-0001-8851-496X)
- Jessica Fernanda Affonso de Oliveira (ORCID: https://orcid.org/0000-0002-5474-2355)
- Sri Vidhya Chandrasekar
Institutions
- Dartmouth College (US)
- Oklahoma State University (US)
- University of California San Diego (US)
- La Jolla Bioengineering Institute (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1566394
- Citations
- 2
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.63