Environmental Risk Factors Are Associated With the Natural History of Familial Dilated Cardiomyopathy
We identified distinct subsets of environmental factors that affect DCM penetrance and trajectory. Our data highlight DCM-promoting environmental factors as key determinants of penetrance and natural history. Collectively, these findings provide a new framework for risk factor assessment in familial DCM and have important implications for clinical management.
Authors
- Quan Huynh (ORCID: https://orcid.org/0000-0003-1368-5160)
- Leah Wright (ORCID: https://orcid.org/0000-0003-3269-6287)
- Mark J. Perrin (ORCID: https://orcid.org/0000-0001-9813-4338)
- Paul A. James (ORCID: https://orcid.org/0000-0002-4361-4657)
- Renée Johnson (ORCID: https://orcid.org/0000-0002-8979-2096)
- Alison H. Trainer (ORCID: https://orcid.org/0000-0002-9847-3265)
- Stacey Peters (ORCID: https://orcid.org/0000-0002-3593-3228)
- Dominica Zentner (ORCID: https://orcid.org/0000-0003-0437-1581)
- Jonathan M. Kalman (ORCID: https://orcid.org/0000-0002-6618-7184)
- Diane Fatkin (ORCID: https://orcid.org/0000-0002-9010-9856)
- Bryony A. Thompson (ORCID: https://orcid.org/0000-0001-8655-1839)
- Thomas Hugh Marwick (ORCID: https://orcid.org/0000-0001-9065-0899)
- Lauren McCall
- Tina Thompson (ORCID: https://orcid.org/0000-0002-9405-6595)
- J. Yao (ORCID: https://orcid.org/0000-0001-8974-4265)
- Celine Santiago (ORCID: https://orcid.org/0000-0002-1549-3667)
Institutions
- St. Vincent's Birmingham (US)
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Victor Chang Cardiac Research Institute (AU)
- Peter MacCallum Cancer Centre (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Melbourne (AU)
- Saint Vincent's Catholic Medical Center (US)
- The Catholic University of Korea St. Vincent's Hospital (KR)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1161/jaha.124.037311
- Citations
- 3
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.16