Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire
We show that a neoantigen-directed T-cell response in tumor-bearing hosts comprises a diverse repertoire. Infiltration and expansion of certain T-cell clonotypes in the tumor do not necessarily correlate with therapeutic efficacy of their TCRs in adoptive therapy. We propose that analysis of persistent rather than immediate responses of TCR-modified T cells in vitro serves as a reliable parameter to identify TCRs that are therapeutically effective in vivo.
Authors
- Hans Schreiber (ORCID: https://orcid.org/0000-0002-1908-6233)
- Poh Yin Yew
- Matthias Leisegang (ORCID: https://orcid.org/0000-0003-3692-7142)
- Johanna Olweus (ORCID: https://orcid.org/0000-0002-1898-3100)
- Thomas J. F. Blankenstein (ORCID: https://orcid.org/0000-0002-3357-4321)
- Steven P. Wolf (ORCID: https://orcid.org/0009-0008-2723-695X)
- Vasiliki Anastasopoulou
- Guoshuai Cao (ORCID: https://orcid.org/0000-0002-9987-4554)
- Leonie Rosenberger
- Erlend Strønen (ORCID: https://orcid.org/0000-0001-9314-9389)
- Jun Huang (ORCID: https://orcid.org/0000-0003-0271-4384)
- Gerald Willimsky (ORCID: https://orcid.org/0000-0002-9693-948X)
- Naresha Saligrama (ORCID: https://orcid.org/0000-0003-2526-7150)
- Leo Hansmann (ORCID: https://orcid.org/0000-0003-3790-0128)
- Taigo Kato (ORCID: https://orcid.org/0000-0002-8681-1407)
- Kimberley Drousch (ORCID: https://orcid.org/0009-0002-6677-8168)
- Yusuke Nakamura (ORCID: https://orcid.org/0000-0003-2956-382X)
- Xinyi Feng (ORCID: https://orcid.org/0000-0001-9051-6091)
- Christina Moewes
Institutions
- Oslo University Hospital (NO)
- German Cancer Research Center (DE)
- University of Oslo (NO)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- University Hospital Regensburg (DE)
- University of Chicago (US)
- Hope Center for Neurological Disorders (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Precision Research (United States) (US)
- Japanese Foundation For Cancer Research (JP)
- Charité - Universitätsmedizin Berlin (DE)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2024-011351
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- University of Chicago
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Einstein Stiftung Berlin
- Deutschen Konsortium für Translationale Krebsforschung
- National Institutes of Health
- European Research Council